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排序方式: 共有88条查询结果,搜索用时 78 毫秒
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Niche Inheritance: A Cooperative Pathway to Enhance Cancer Cell Fitness Through Ecosystem Engineering 下载免费PDF全文
Kimberline R Yang Steven M. Mooney Jelani C. Zarif Donald S. Coffey Russell S. Taichman Kenneth J. Pienta 《Journal of cellular biochemistry》2014,115(9):1478-1485
Cancer cells can be described as an invasive species that is able to establish itself in a new environment. The concept of niche construction can be utilized to describe the process by which cancer cells terraform their environment, thereby engineering an ecosystem that promotes the genetic fitness of the species. Ecological dispersion theory can then be utilized to describe and model the steps and barriers involved in a successful diaspora as the cancer cells leave the original host organ and migrate to new host organs to successfully establish a new metastatic community. These ecological concepts can be further utilized to define new diagnostic and therapeutic areas for lethal cancers. 115: 1478–1485, 2014. © 2014 Wiley Periodicals, Inc. 相似文献
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Stefan Rozel Craig J. Galbán Klaas Nicolay Kuei C. Lee Sudha Sud Chris Neeley Linda A. Snyder Thomas L. Chenevert Alnawaz Rehemtulla Brian D. Ross Kenneth J. Pienta 《Journal of cellular biochemistry》2009,107(1):58-64
Metastatic prostate cancer continues to be the second leading cause of cancer death in American men with an estimated 28,660 deaths in 2008. Recently, monocyte chemoattractant protein‐1 (MCP‐1, CCL2) has been identified as an important factor in the regulation of prostate metastasis. CCL2, shown to attract macrophages to the tumor site, has a direct promotional effect on tumor cell proliferation, migration, and survival. Previous studies have shown that anti‐CCL2 antibodies given in combination with docetaxel were able to induce tumor regression in a pre‐clinical prostate cancer model. A limitation for evaluating new treatments for metastatic prostate cancer to bone is the inability of imaging to objectively assess response to treatment. Diffusion‐weighted MRI (DW‐MRI) assesses response to anticancer therapies by quantifying the random (i.e., Brownian) motion of water molecules within the tumor mass, thus identifying cells undergoing apoptosis. We sought to measure the treatment response of prostate cancer in an osseous site to docetaxel, an anti‐CCL2 agent, and combination treatments using DW‐MRI. Measurements of tumor apparent diffusion coefficient (ADC) values were accomplished over time during a 14‐day treatment period and compared to response as measured by bioluminescence imaging and survival studies. The diffusion data provided early predictive evidence of the most effective therapy, with survival data results correlating with the DW‐MRI findings. DW‐MRI is under active investigation in the pre‐clinical and clinical settings to provide a sensitive and quantifiable means for early assessment of cancer treatment outcome. J. Cell. Biochem. 107: 58–64, 2009. © 2009 Wiley‐Liss, Inc. 相似文献
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A Bayesian hierarchical model for prediction of latent health states from multiple data sources with application to active surveillance of prostate cancer 下载免费PDF全文
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Nuclear structure and the three-dimensional organization of DNA. 总被引:11,自引:0,他引:11
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Liang Dong Richard C. Zieren Yanqing Wang Theo M. de Reijke Wei Xue Kenneth J. Pienta 《生物化学与生物物理学报:癌评论》2019,1871(2):342-360
Urological malignancies, including prostate cancer, bladder cancer and kidney cancer, are major causes of morbidity and mortality worldwide. Because of the high incidence, diversity in biology, and especially direct interaction with urine, urological cancers are an important resource for both scientists and clinicians for novel diagnostic and therapeutic discovery. Extracellular vesicles (EVs) are lipid bilayer encapsulated particles released by cells into the extracellular space. Since EVs work as a safe way to transport important biological information through the whole body, they are now recognized as an important mechanism of cell–cell communication and have opened a new window for us to gain a better understanding of cancer biology, novel diagnostics, and therapeutic options. In recent years, numerous evolutions in EV technologies and novel biological and clinical findings continue to be reported in the research field of urological cancers. This comprehensive review aims to give an update of recent advances in EV technologies and summarize the state-of-the-art knowledge of EVs related to prostate cancer, bladder cancer and kidney cancer, particularly focusing on the potential of EV as biomarkers and their biological roles in promoting cancer and metastasis. 相似文献
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R. F. Schuman R. J. Pienta J. A. Poiley W. B. Lebherz III 《In vitro cellular & developmental biology. Plant》1979,15(9):730-735
Summary Eighteen lots of fetal bovine serum were tested for their ability to support clonal growth and 3-methylcholanthrene-induced
morphological transformation of hamster embryo cells in vitro. Most of them supported cloning efficiencies of over 11%. However,
cloning efficiency alone was an inadequate criterion for selecting serum for transformation studies, since no transformation
was observed with some lots, even though their cloning efficiencies were over 16%. This shows the importance of pretesting
serum for its ability to support morphological transformation before it is used in mammalian cell carcinogenesis tests.
Research sponsored by the National Cancer Institute under Contract No. N01-CO-75380 with Litton Bionetics, Inc. 相似文献